نتایج جستجو برای: huperzine a

تعداد نتایج: 13431799  

Journal: :Journal of pharmaceutical and biomedical analysis 2010
Lygia Azevedo Marques Martin Giera Frans J J de Kanter Wilfried M A Niessen Henk Lingeman Hubertus Irth

A new photoisomer of the promising "anti-Alzheimer" drug candidate (+/-) huperzine A is described. The new substance was formed via a photoisomerization reaction and was found to be 1-amino-13-ethylidene-11-methyl-6-aza-tetracyclo-[7.3.1.0(2.7).0(4.7)]-trideca-2,10-diene-5-one using NMR analysis. The kinetics of its formation was studied and proven to be of first-order. The described photoisome...

2014
Huilin Yang Ya Wang Zhibin Zhang Riming Yan Du Zhu

Here, we report the draft genome sequence of Shiraia sp. strain Slf14 (China Center for Type Culture Collection [CCTCC] no. 209294), which is used to produce huperzine A and hypocrellin A. The genome sequence will allow for the characterization of the molecular mechanisms underlying its beneficial properties.

Journal: :iranian journal of pharmaceutical research 0
jun shi 1- school of pharmacy, east china university of science and technology, shanghai 200237, pr china. 2- department of chemistry, tsinghua university, beijing 100084, pr china. wen-juan cong engineering research center of modern preparation technology of tcm (ministry of education), shanghai university of traditional chinese medicine, shanghai 201203, pr china. yi-ming wang department of chemistry, tsinghua university, beijing 100084, pr china. qing-fei liu school of medicine, tsinghua university, beijing 100084, pr china. guo-an luo 1- school of pharmacy, east china university of science and technology, shanghai 200237, pr china. 2- department of chemistry, tsinghua university, beijing 100084, pr china.

the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

2015
Guowei Zhang Wenjuan Wang Xiangmei Zhang Qianqian Xia Xinmei Zhao Youngjoon Ahn Nevin Ahmed Andreea Cosoveanu Mo Wang Jialu Wang Shaohua Shu

Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these plants. Various endophytic fungi produce huperzine A. Colletotrichum gloeosporioides ES026 was previously isolated from a huperzine-A-producing...

Journal: :Zhongguo yao li xue bao = Acta pharmacologica Sinica 1996
J H Lin G Y Hu X C Tang

AIM To study the effects of huperzine-A on neuromuscular junction transmission in mouse. METHODS The isolated mouse phrenic nervehemidiaphragm preparations were used with the conventional intracellular recording technique. The spontaneous electrical activities of cholinergic nerve terminals (miniature end-plate potentials, MEPP) were recorded. RESULTS Huperzine-A, tacrine, and E2020 at the ...

2015
Yun Lei Ling Yang Chun Yan Ye Ming Yan Qin Huai Yu Yang Hua Liang Jiang Xi Can Tang Hai Yan Zhang Donghui Zhu

Considerable studies indicate huperzine A is a promising natural product to suppress neuronal damages induced by β-amyloid (Aβ), a key pathogenic event in the Alzheimer's disease (AD). As an extension, the present study for the first time explored whether the beneficial profiles of huperzine A against oligomeric Aβ(42) induced neurotoxicity are associated with the accumulation and detrimental f...

2013
LEIMING ZHANG YANQIN SONG CHENGWEN LU JIANQIAO ZHANG JIANI YUAN TIAN WANG FENGHUA FU

The acetylcholinesterase inhibitor (AChEI), huperzine A has been used in the treatment of the cognitive deterioration associated with Alzheimer's disease (AD). However, the side-effects of huperzine A associated with increased cholinergic activity, particularly in the gastrointestinal system, are evident. It is not yet known how quickly these side-effects become tolerated; this information woul...

2007
Jiri Bajgar Petr Hajek Jana Karasova Dasa Slizova Otakar Krs Kamil Kuca Daniel Jun Josef Fusek Lukas Capek

Acetylcholinesterase (AChE) activities in different brain parts were determined quantitatively in rats treated with huperzine A, soman, and huperzine A followed by soman, using histochemical and biochemical methods. Following soman intoxication (1.2 x LD50, i.m.), AChE activity was decreased to 30-80% of control values depending on the brain structure. The most sensitive area was the frontal co...

2013
Guoyan Yang Yuyi Wang Jinzhou Tian Jian-Ping Liu

BACKGROUND Huperzine A is a Chinese herb extract used for Alzheimer's disease. We conducted this review to evaluate the beneficial and harmful effect of Huperzine A for treatment of Alzheimer's disease. METHODS We searched for randomized clinical trials (RCTs) of Huperzine A for Alzheimer's disease in PubMed, Cochrane Library, and four major Chinese electronic databases from their inception t...

The aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine A from microemulsions, andtheir potential synergistic effect on the permeation enhancement. The transdermal deliveryof huperzine A from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

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